The Effects of Anorexic Doses of dextro-Amphetamine on the Ventromedial-Hypothalamic Hyperphagic Rat

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Abstract
Rats were made hyperphagic by the production of electrolytic lesions in the ventromedial hypothalamus. Following a recovery period during which a rapid weight gain was observed, d-amphetamine was administered intraperitoneally in various dosages, and food intakes, water intakes, and body weight changes were measured after a 3 h feeding period. A dosage of 0.2 mg/kg d-amphetamine had no observable effect. Increasing the dosage to 0.5 or 1.0 mg/kg, however, significantly depressed food and water intakes, and resulted in reduced weight gains in control and experimental animals. Furthermore, the dose–response curves for both experimental and control groups were similar, indicating that d-amphetamine has the same effect in the hyperphagic rat as in the control. It is concluded that amphetamine anorexia is not mediated by the ventromedial hypothalamus.

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