Primary structure and functional expression of a mouse inward rectifier potassium channel
- 11 March 1993
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 362 (6416) , 127-133
- https://doi.org/10.1038/362127a0
Abstract
A complementary DNA encoding an inward rectifier K+ channel (IRK1) was isolated from a mouse macrophage cell line by expression cloning. This channel conducts inward K+ current below the K+ equilibrium potential but passes little outward K+ current. The IRK1 channel contains only two putative transmembrane segments per subunit and corresponds to the inner core structure of voltage-gated K+ channels. The IRK1 channel and an ATP-regulated K+ channel show extensive sequence similarity and constitute a new superfamily.Keywords
This publication has 54 references indexed in Scilit:
- Calcium-activated potassium channels expressed from cloned complementary DNAsPublished by Elsevier ,1992
- Voltage-sensing residues in the S4 region of a mammalian K+ channelNature, 1991
- Glial ion channelsCurrent Opinion in Neurobiology, 1991
- Characterization of a mammalian cDNA for an inactivating voltage-sensitive K+ channelNeuron, 1991
- Expression of an inwardly rectifying K+ channel from rat basophilic leukemia cell mRNA in Xenopus oocytesFEBS Letters, 1991
- A Component of Calcium-activated Potassium Channels Encoded by the Drosophila slo LocusScience, 1991
- Potassium channels from NG108‐15 neuroblastoma‐glioma hybrid cellsFEBS Letters, 1989
- Inwardly rectifying whole-cell and single-channel K currents in the murine macrophage cell line J774.1The Journal of Membrane Biology, 1988
- The Use ofXenopusOocytes for the Study of Ion ChannelCritical Reviews in Biochemistry, 1987
- Dual effects of K ions upon the inactivation of the anomalous rectifier of the tunicate egg cell membraneThe Journal of Membrane Biology, 1980