Effect of Nisoldipine upon the General and Coronary Hemodynamics of the Anesthetized Dog

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Abstract
The effect of nisoldipine (5 μg/kg/i.v.) was studied in anesthetized intact dogs. This calcium antagonist increased heart rate by 68%, doubled cardiac output, and increased coronary sinus flow from 62 ± 10 ml/min to a maximum of 131 ± 7 ml/min. Mean systemic pressure decreased from 125 ± 10 mm Hg to a minimum of 115 ± 2 mm Hg for at least 15 min after the injection. Mean pulmonary artery pressure increased from 12 ± 2 mm Hg to 18 ± 4 mm Hg within 2 min of the injection. Left ventricular work (joules/s) doubled and right ventricular work trebled during the first 15 min after injection. Peripheral resistance fell by 57%, total pulmonary resistance by 40%, and coronary vascular resistance by half. Coronary sinus O2 content increased by 50%. and cardiac efficiency (index) increased from 0.2 (control) to a maximum of 0.46. within 2 min after the injection of the drug.

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