Potassium Iodide Sensitivity in Four Patients with Hypocomplementemic Vasculitis

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Abstract
During metabolism sutdies of radiolabeled proteins in 126 participants, 4 patients were suspected of being sensitive to KI because they repeatedly developed urticaria and other symptoms after KI administration. Two of the 4 patients suspected of KI sensitivity and 10 control patients were orally challenged with KI to document and characterize KI sensitivity and to evaluate the possible association(s) of KI sensitivity with urticaria, hypocomplementemia and vasculitis. KI challenges in the 2 sensitive patients precipitated urticaria, angioedema, polymyalgias, conjunctivitis and coryza. One of these 2 patients also developed a severe systemic illness characterized by fever, headache, peritonitis, episcleritis and pneumonitis. The 4 sensitive patients were strikingly similar in that they exhibited hypocomplementemia and dermal vasculitis associated with chronic urticaria or systemic lupus erythematosus, suggesting that other patients with similar clinical features may be sensitive to KI and that KI may precipitate severe systemic illness in them.

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