Inhibition of Carcinogenic and Toxic Effects of Polycyclic Hydrocarbons by Phenolic Anti-oxidants and Ethoxyquin2

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Abstract
The antioxidants butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), and ethoxyquin inhibited the carcinogenicity of benzo[a]pyrene or 7,12-dimethylbenz[a]anthracene (DMBA) on the forestomach of the mouse. They also inhibited mammary tumor formation produced by oral administration of DMBA to female Sprague-Dawley rats. Alpha-tocopherol was ineffective in both the mouse and rat experiments. BHA and alpha-tocopherol did not suppress initiation of epidermal neoplasia in the mouse by DMBA. In 2 studies of the effects of antioxidants on DMBA toxicity, BHA decreased the lethality in mice of a high concentration of DMBA in the diet, and BHA, BHT, and ethoxyquin given to female rats 1 hour before oral administration of 30 mg DMBA prevented the adrenal necrosis occurring in animals not given the antioxidants.

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