Enantioselective Hydrolysis of N-Acylated α-Amino Esters at a Biphasic Interface: Tandem Reaction Kinetic Resolution Using a Chiral Complexing Agent
- 29 August 2002
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 4 (19) , 3283-3286
- https://doi.org/10.1021/ol026517s
Abstract
[reaction: see text] Highly enantioselective hydrolytic kinetic resolutions of esters derived from N-acylated alpha-amino acids proceed rapidly at hydrocarbon/water interfaces in the presence of a proline-derived chiral selector. When performed in tandem with an enantioselective biphasic esterification reaction, esters of 100% enantiomeric excess are obtainedKeywords
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