Trace Determination of Chlorpheniramine in Plasma by GLC Using a Nitrogen-Phosphorous (N-P) Detector
- 1 November 1978
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Chromatographic Science
- Vol. 16 (11) , 561-564
- https://doi.org/10.1093/chromsci/16.11.561
Abstract
A fast, sensitive and specific method for the determination of chlorpheniramine in plasma is described. The drug was extracted with diethylether, back extracted in hydrochloric acid and reextracted in diethylether. The extract was evaporated to dryness and reconstituted in isopropyl alcohol. The isopropyl alcoholic solution was gas chromatographed without any derivatization and the detection was carried out using a nitrogen sensitive detector. The mean recovery of chlorpheniramine was found to be 96% and a drug level as low as 0.5 ng/ml can be accurately measured.This publication has 4 references indexed in Scilit:
- Simultaneous GLC Determination of Phenylpropanolamine and Chlorpheniramine in Urine Using a Nitrogen Selective DetectorJournal of Pharmaceutical Sciences, 1978
- Simplified gas chromatographic method for the determination of chlorpheniramine in serumAnalytical Chemistry, 1977
- Determination of brompheniramine in blood and urine by gas-liquid chromatographyAnalytical Chemistry, 1968
- Urinary Excretion of Chlorpheniramine and Its N-Demethylated Metabolites in ManJournal of Pharmaceutical Sciences, 1968