Characterization of High-level Aminoglycoside Resistance in a Strain of Streptococcus pneumoniae
- 1 July 1984
- journal article
- research article
- Published by Microbiology Society in Microbiology
- Vol. 130 (7) , 1665-1671
- https://doi.org/10.1099/00221287-130-7-1665
Abstract
The aminoglycoside phosphotransferase (APH)(3′)(5″)-III has been characterized from Streptococcus pneumoniae BM4200, which is resistant to high levels of aminoglycosides. The phosphotransferase was apparently chromosomally-encoded and was responsible for the high-level resistance. The enzyme was not notably pH-dependent, was heterogeneous after isoelectric focusing, with pI values of approximately 4·8 and 5·1, and had an apparent molecular weight of 32500 after SDS-PAGE.This publication has 13 references indexed in Scilit:
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