Mitogenic leukoagglutinin from Phaseolus vulgaris binds to a pentasaccharide unit in N-acetyllactosamine-type glycoprotein glycans.

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Abstract
The carbohydrate binding specificity of leukoaglutinin (La; P. vulgaris isolectin L4) was studied using quantitative precipitation and precipitation-inhibition. A series of purified glycopeptides and synthetic oligosaccharides were used as inhibitors. The minimal structural unit required for La binding was the disaccharide .**GRAPHIC**. Additions for this basic unit of different sugar residues gave a positive or negative contribution to binding. The most complementary structure was that of a pentasaccharide, the structure of which is described.