Olsalazine in Patients Intolerant of Sulphasalazine
- 1 January 1987
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Gastroenterology
- Vol. 22 (9) , 1038-1040
- https://doi.org/10.3109/00365528708991953
Abstract
Fifty patients with ulcerative colitis, intolerant of sulphasalazine, were treated with 500 mg olsalazine twice daily for a 3-month trial period. Thirty-eight of the patients (76%) tolerated the drug well, and all continued to take it beyond the 3-month period. Twelve (24%) were withdrawn because of side effects, the commonest being diarrhea. There were in haematologic or biochemical abnormalities. Thus, olsalazine is a useful drug for patients who are intolerant of sulphasalazine.This publication has 15 references indexed in Scilit:
- Effect of azodisal sodium and sulphasalazine on ileostomy output of fluid and PGE2 and PGF2 alpha in subjects with a permanent ileostomy.Gut, 1986
- Olsalazine in active ulcerative colitis.BMJ, 1985
- Reversible male infertility due to sulphasalazine: studies in man and rat.Gut, 1984
- TREATMENT OF ULCERATIVE COLITIS WITH ORAL 5-AMINOSALICYLIC ACID IN PATIENTS UNABLE TO TAKE SULPHASALAZINEThe Lancet, 1983
- SulfasalazineDigestive Diseases and Sciences, 1983
- Absorption and Excretion of a Single 1-g Dose of Azodisal Sodium in Subjects with IleostomyScandinavian Journal of Gastroenterology, 1983
- Distribution and metabolism in healthy volunteers of disodium azodisalicylate, a potential therapeutic agent for ulcerative colitis.Gut, 1982
- Incidence of sulphasalazine-induced male infertility.Gut, 1981
- AN EXPERIMENT TO DETERMINE THE ACTIVE THERAPEUTIC MOIETY OF SULPHASALAZINEThe Lancet, 1977
- Absorption, metabolism, and excretion of salicylazosulfapyridine in manClinical Pharmacology & Therapeutics, 1972