Deficiency of T cell mediated regulation of anti‐dna production in systemic lupus erythematosus
Open Access
- 1 January 1980
- journal article
- research article
- Published by Wiley in Arthritis & Rheumatism
- Vol. 23 (1) , 24-29
- https://doi.org/10.1002/art.1780230105
Abstract
Isolated B cells from normal subjects and patients with systemic lupus erythematosus (SLE) could be stimulated to produce IgM anti‐DNA with pokeweed mitogen. Normal but not SLE allogeneic T cells abrogated this response. Normal but not SLE autologous T cells promoted a switch from IgM to IgG anti‐DNA production. SLE is characterized by at least two types of immunoregulatory abnormalities: a defect in T suppressor function and a defect in the IgM to IgG switchover.This publication has 16 references indexed in Scilit:
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