Basal, cAMP- and cGMP-dependent protein kinases in human brain tumors

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Abstract
Since the effects of cyclic nucleotides are mediated via protein kinase activation, the properties and regulation of these enzymes in cytosol and particulate fraction of normal cerebral tissues and of some human brain tumors was studied. Distribution and activity of cyclic nucleotide-dependent protein kinases are regulated differently among various brain tumors and in comparison to normal gray and white matter. Pathological tissues show a higher c[cyclic]GMP-dependent protein kinase and this biochemical pattern is particularly evident in tumors with more pronounced malignancy. The hypothesis of a correlation between the increase of cGMP function and cellular growth and malignancy is confirmed.