Functional evidence for altered activity of gabaergic receptors following chronic desipramine treatment in rats
- 1 December 1986
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 38 (12) , 934-935
- https://doi.org/10.1111/j.2042-7158.1986.tb03389.x
Abstract
The antinociceptive effect of subcutaneous 4,5,6,7-tetrahydroisoxazol[5,4-c]pyridin-3-ol (THIP) or (±)-baclofen, measured as reaction time of rats placed on a plate heated to 55 °C, was assessed after a single or the last repeated (18 consecutive days) dose (5 mg kg−1 once daily) of subcutaneous desipramine. Baclofen (10 mg kg−1)-induced antinociception was reduced by acute and unaffected by chronic desipramine treatment. On the contrary, THIP (20 mg kg−1)-induced antinociception was unaffected by acute and reduced by chronic desipramine.This publication has 8 references indexed in Scilit:
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