Hybrid photoacoustic fluorescence molecular tomography using finite‐element‐based inversion

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Abstract
Improvements in fluorescence reconstruction when utilizing a hybrid photoacoustic (PAT) fluorescence molecular tomography (FMT) method to image optically heterogeneous media are studied and showcased. Quantitative optical absorption maps are retrieved using a normalized backprojection algorithm for PAT reconstruction. Consecutively, the reconstructed absorption distribution is employed into computing a diffusion‐equation‐based forward model for FMT using a finite‐element solution. The potential promise of the suggested method is experimentally verified on tissue‐mimicking fluorescent phantoms, where improvements in the quality of FMT reconstructions are observed when imaging at the presence of a large absorber.