Bordetella pertussisAdenylate Cyclase-Hemolysin Induces Interleukin-6 Secretion by Human Tracheal Epithelial Cells
Open Access
- 1 September 2004
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 72 (9) , 5530-5533
- https://doi.org/10.1128/iai.72.9.5530-5533.2004
Abstract
After interaction with tracheal epithelial cells, Bordetella pertussis induces the secretion of interleukin-6. This secretion is dependent on the expression of adenylate cyclase-hemolysin by the bacterium but not on the expression of other characterized bacterial toxins or adhesins. This finding confirms the important role of adenylate cyclase-hemolysin in the pathogenicity of the bacterium.Keywords
This publication has 52 references indexed in Scilit:
- Adenylate Cyclase Toxin fromBordetella pertussisSynergizes with Lipopolysaccharide To Promote Innate Interleukin-10 Production and Enhances the Induction of Th2 and Regulatory T CellsInfection and Immunity, 2004
- Induction of Proinflammatory Cytokines in Human Lung Epithelial Cells duringChlamydia pneumoniaeInfectionInfection and Immunity, 2003
- Regulation of Proinflammatory Cytokines in Human Lung Epithelial Cells Infected withMycoplasma pneumoniaeInfection and Immunity, 2002
- Mechanisms of bordetella pathogenesisFrontiers in Bioscience-Landmark, 2001
- Infection and Activation of Airway Epithelial Cells byChlamydia pneumoniaeThe Journal of Infectious Diseases, 2000
- Induction of Proinflammatory Cytokines from Human Respiratory Epithelial Cells after Stimulation by NontypeableHaemophilus influenzaeInfection and Immunity, 2000
- Activation of NF-kappaB by adherent Pseudomonas aeruginosa in normal and cystic fibrosis respiratory epithelial cells.Journal of Clinical Investigation, 1998
- CD14/LPS receptor exhibits lectin-like propertiesInnate Immunity, 1996
- Effect of Haemophilus influenzae endotoxin on the synthesis of IL-6, IL-8, TNF-alpha and expression of ICAM-1 in cultured human bronchial epithelial cellsEuropean Respiratory Journal, 1994
- Novel Pseudomonas product stimulates interleukin-8 production in airway epithelial cells in vitro.Journal of Clinical Investigation, 1994