EFFECT OF SOME BETA-ADRENERGIC BLOCKING-DRUGS ON RENAL BLOOD-FLOW IN DOGS

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 229  (2) , 227-234
Abstract
Using timed collection of blood returning via the renal veins, the renal blood flow was determined in anesthetized dogs following the i.v. injection of 3 .beta.-adrenergic blockers, i.e., propranolol, oxprenolol and pindolol. The drugs were given as a bolus or as an infusion, and their effects on the renal blood flow and blood pressure were studied. The drugs produced diminution in the renal blood flow and blood pressure. These effects were variable in degree. The diminution in the renal blood flow under the influence of .beta.-adrenergic blockers might be explained by concomitant reduction in the cardiac output and/or blockade of the renal vasodilator .beta.-adrenergic receptors. An added factor might be sympathetic stimulation with consequent renal vasoconstriction in the case of blockers with intrinsic sympathomimetic activity. .beta.-Adrenergic blocking drugs should be given with extreme caution in cases with impaired renal function.