THE EFFECTS OF TRICHLOROETHYLENE ON LIMB BLOOD FLOW IN MAN

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Abstract
Limb blood flow was studied in twelve subjects, during trichloroethylene anaesthesia, using venous occlusion plethysmography. There was no significant alteration in blood flow or vascular resistance in the series as a whole. In some cases there was evidence of peripheral vasodilatation which was not abolished by nerve block. This was associated with tachypnoea and it was considered to be the result of the action of trichloroethylene on the blood vessel wall. Vasodilatation during trichloroethylene anaesthesia was replaced by vasoconstriction when the tachypnoea was abolished by means of intravenous pethidine. It is suggested that this is a compensatory vasoconstriction in response to a fall in the cardiac output, brought about by the combined effects of the narcotic and the anaesthetic agent.

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