Excitatory amino acid release in the locus coeruleus during naloxone-precipitated morphine withdrawal in adjuvant arthritic rats
- 1 January 2000
- journal article
- research article
- Published by Springer Nature in Inflammation Research
- Vol. 49 (1) , 36-41
- https://doi.org/10.1007/pl00000201
Abstract
Objective and Design: Excitatory amino acid levels in the locus coeruleus (LC) and the behavioral signs during naloxone-precipitated withdrawal in arthritic rats treated with chronic morphine were investigated by in vivo microdialysis.¶Methods: Increases in glutamate (Glu) and aspartate (Asp) were noted after naloxone (48 nmol/5 μl, LC)-precipitated withdrawal from normal and adjuvant arthritic rats which had been intracerebroventricularly infused for 3 days with morphine (26 nmol/1 μl/h).¶Results: The increases in Glu and Asp levels on morphine withdrawal in normal rats were attenuated following naloxone challenge in the morphine-dependent arthritic rats. Moreover, behavioral signs during morphine withdrawal were detected following the naloxone challenge in both the morphine-dependent normal and adjuvant arthritic rats, but not in the saline-infused controls.¶Conclusions: These results show that the attenuation of Glu and Asp release from the LC in the adjuvant arthritic rats might explain the anti-inflammatory and analgesic effects of μ-opioids in adjuvant arthritic rats.¶Keywords
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