Amyotrophic lateral sclerosis: a double-blind crossover trial of thyrotropin-releasing hormone.
Open Access
- 1 December 1984
- journal article
- clinical trial
- Published by BMJ in Journal of Neurology, Neurosurgery & Psychiatry
- Vol. 47 (12) , 1332-1334
- https://doi.org/10.1136/jnnp.47.12.1332
Abstract
A double-blind crossover trial was conducted of thyrotropin releasing hormone treatment in six patients with amyotrophic lateral sclerosis. Patients received 4 mg of thyrotropin releasing hormone intramuscularly daily during the two-week treatment period. Although three patients reported subjective improvement, objective evaluation failed to demonstrate therapeutic effectiveness of thyrotropin releasing hormone in this dosage.Keywords
This publication has 6 references indexed in Scilit:
- Controlled trial of thyrotropin releasing hormone tartrate in ataxia of spinocerebellar degenerationsJournal of the Neurological Sciences, 1983
- EFFECT ON WEAKNESS AND SPASTICITY IN AMYOTROPHIC LATERAL SCLEROSIS OF THYROTROPIN-RELEASING HORMONEThe Lancet, 1983
- Stimulant action of thyrotropin releasing hormone on cat spinal cordNeuropharmacology, 1978
- Thyrotropin-releasing hormone (TRH) in rat spinal cordBrain Research, 1977
- Distribution of thyroptropin-releasing hormone (TRH) in the central nervous system as revealed with immunohistochemistryEuropean Journal of Pharmacology, 1975
- Thyrotropin-Releasing Hormone: Regional Distribution in Rat BrainScience, 1974