Restoration of Testicular Transferring Insulin-Likegrowth Factor-1 (IGF-1), and Spermatogenesis by Exogenously Administered Purified FSH and Testosterone in Medically Hypophysectomized Rats
- 1 January 1994
- journal article
- Published by Taylor & Francis in Archives of Andrology
- Vol. 33 (3) , 169-177
- https://doi.org/10.3109/01485019408987821
Abstract
To investigate the relation between testicular transferrin and insulin-like growth factor-1 (IGF-1) secreted by Sertoli cells and the differentiation of germ cells in the rat, testosterone and/or purified FSH was administered to rats medically hypophysectomized by an LH-RH agonist. Spermatogenesis was quantitatively analyzed and concentrations of intratesticular transferrin and IGF-1 were measured by radioimmunoassays. The last step of spermatogenesis was quantitatively restored by combined administration of testosterone and purified FSH. Intratesticular IGF-1 concentrations were significantly increased by combined administration of testosterone and purified FSH. From these observations, it is surmised that IGF-1 may have a stimulatory effect on the last step of spermatogenesis.Keywords
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