Chemotherapy of Rodent Malaria

Abstract
A technique is described in this report for the evaluation of drug interactions with combinations containing only one active antimalarial agent. The relative merits of chloroquine-resistant strains of P.berghei and P.yoelii ssp. as laboratory models of P.falciparum are discussed. Blood schizontocidal action of 8 WRAIR compounds and 1 compound from another source is summarised. Data from cross-resistance studies on 29 different sensitive and resistant strains are included. In a series of drug interaction tests to determine the influence of 4 WRAIR compounds on the action of chloroquine against chloroquine- resistant P.yoelii ssp. NS strain, only WR 014044 enhanced the activity of chloroquine. A high degree of synergism was demonstrated with a combination of two different isomers of the floxacrine analog WR 243251.

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