Dose-dependent Responses to Endotoxin in the Dog.

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Abstract
Summary Dogs injected with S. marcescens lipopolysaccharide at graded dose levels between 0.01 and 1.0 mg/kg responded with characteristic sudden portal pressure elevations and arterial hypotension. The magnitude of these alterations and of the acidosis and hemoconcentration which ultimately develop in endotoxin treated animals were positively related to dose level. At doses less than 1 mg/kg no immediate relationship was evident between initial circulatory response and mortality rate. This suggests that the initial circulatory alterations which may result from the histamine-releasing properties of endotoxin can be reversed. The lethal property of endotoxin may reside in the secondary irreversible impairments it induces.