The Crystal and Molecular Structure of (3-Morpholinopropyl)diphenylsilanol.
- 1 January 1984
- journal article
- research article
- Published by Danish Chemical Society in Acta Chemica Scandinavica
- Vol. 38b (2) , 95-99
- https://doi.org/10.3891/acta.chem.scand.38b-0095
Abstract
(3-Morpholinopropyl)diphenylsilanol, C19H25NO2Si, MW = 327.5, triclinic, space group P.hivin.1, a = 15.073(4) .ANG., b = 9.678(3) .ANG., c = 6.770(3) .ANG., .alpha. = 99.04(2).degree., .beta. = 95.84(2).degree., .gamma. = 103.90(2).degree., V = 936.68 .ANG.3, Z = 2, Dx = 1.16 Mg/m3, .mu.(CuK.alpha.)= 1.146/mm1, F(000) = 352. The intensities of 3308 unique reflections were measured on an automatic diffractometer. The structure was solved by direct methods and refined by full-matrix least-squares calculations using 3281 reflections to a final Rw-value of 0.072. The molecules are held together by O.sbd.H.cntdot..cntdot..cntdot.N hydrogen bonds [2.840(3) .ANG.] thereby forming infinite chains which build up the structure. The morpholine ring has a chair form conformation. [The title compound is closely related to the anticholinergic drugs difenidol (1,1-diphenyl-4-piperidino-1-butanol) and sila-difenidol (3-piperidinopropyl)diphenylsilanol.].Keywords
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