MORPHOLOGY OF SPONTANEOUS AND INDUCED-TUMORS IN THE BRONCHIOLO-ALVEOLAR REGION OF F344 RATS
- 1 January 1982
- journal article
- research article
- Vol. 2 (1-2) , 53-57
Abstract
The morphology of spontaneous and chemically-induced metastasizing carcinomas and adenomas in the bronchiolo-alveolar region of F-344 rats was studied. Histologically, the tumors were tubulo-papillary. Ultrastructurally, they consisted of cells which formed and secreted osmiophilic lamellated inclusion bodies, a marker of alveolar type II cells. Mitotic tumor cells also demonstrated such bodies. No cells of bronchial or bronchiolar origin were found in the tumors. In F344 rats, lung tumors located in the bronchiolo-alveolar region apparently consist of alveolar type II cells exclusively and are, therefore, alveolar cell adenomas and caromas, respectively. [The chemical carcinogens included N-nitrosomethylurethane, N-nitrosoheptamethyleneimine, tris(2,3-dibromopropyl)phosphate, 2,5-dithiourea and 3-nitropropionic acid.].This publication has 7 references indexed in Scilit:
- HISTOLOGIC AND ULTRASTRUCTURAL FEATURES OF THE CLARA CELL ADENOMA OF THE MOUSE LUNG1979
- Carcinogenicity of N -Nitrosodiethylamine in Hibernating and Nonhibernating European Hamsters 2JNCI Journal of the National Cancer Institute, 1977
- Ultrastructural alterations of Apud cells during nitrosamine‐induced lung carcinogenesisThe Journal of Pathology, 1977
- PULMONARY CARCINOMA (JAAGSIEKTE) OF SHEEP - ULTRASTRUCTURAL-STUDY OF EARLY AND ADVANCED TUMOR LESIONS1977
- SEQUENTIAL MORPHOLOGIC ALTERATIONS IN BRONCHIAL EPITHELIUM OF SYRIAN GOLDEN-HAMSTERS DURING N-NITROSOMORPHOLINE-INDUCED PULMONARY TUMORIGENESIS1977
- ULTRASTRUCTURAL ALTERATIONS OF NON-CILIATED CELLS AFTER NITROSAMINE TREATMENT AND THEIR SIGNIFICANCE FOR PULMONARY CARCINOGENESIS1976
- ULTRASTRUCTURE AND FORMATION OF LAMELLATED INCLUSION-BODIES IN INDUCED LUNG TUMORS OF EUROPEAN HAMSTER1976