Microbial conversion of steffimycin and steffimycin B to 10-dihydrosteffimycin and 10-dihydrosteffimycin B.
- 1 January 1980
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 33 (8) , 819-823
- https://doi.org/10.7164/antibiotics.33.819
Abstract
Steffimycin (1) and steffimycin B (2) are reduced at the C-10 carbonyl by Actinoplanes utahensis, UC-5885 and Chaetomium sp., UC-4634, respectively. Using cell-free extracts of the latter organism, the optimum conversion time, pH and enzyme concentration were determined for the conversion of 2 and 4. The biochemical conversion of 2 was TPNH linked.This publication has 6 references indexed in Scilit:
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