ULTRASTUCTURE OF CARTILAGINOUS TUMORS AND S‐100 PROTEIN IN THE TUMORS: With Reference to the Histogenesis of Chondroblastoma, Chondromyxoid Fibroma and Mesenchymal Chondrosarcoma

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Abstract
Twelve cartilaginous tumors were studied by electron microscopy and the presence of S‐100 protein was studied immunohistochemically in order to clarify the cell origin of chondroblastoma, chondromyxoid fibroma, and mesenchymal chondrosarcoma. Three chondroblastomas were characterized by round or ovoid tumor cells with some cytoplasmic processes, well‐developed organelles and thick fibrous laminae in the nuclear membrane, occasional multinucleated giant cells and scanty chondroid matrix. S‐100 protein was demonstrated in the tumor cells and some multinucleated giant cells. Two chondromyxoid fibromas revealed tumor cells of varied shapes with character istic cartilaginous differentiation and abundant chondroid matrix. Spindle tumor cells showed the ultrastructural features of cartilage cells rather than of fibroblasts and S‐100 protein was also demontratrated in their cytoplasm. Chondroblastoma and chondomyxoid fibroma were considered to arise from chondrocytes. Mesenchymal chondrosarcoma ultrastructurally exhibited round tumor cells with cartilaginous nature in cartilage islands. Poorly‐differentiated portions were composed of primitive round or elongated cells with occasionally admixed round cells with ultrastructural features of cartilaginous differentiation. S‐100 protein was demonstrated in the cells in cartilage islands and in single cells admixed in poorly‐differentiated portions. These results support the hypothesis of primitve mesenchymal origin with a tendency to differentiate toward cartilage cells. ACTA PATHOL. JPN. 34: 1285–1300, 1984.