Immunologic Treatment of Alzheimer's Disease

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Abstract
The recent report by Schenk et al.1 raises the hope of a vaccine for Alzheimer's disease. This report has justifiably received wide attention in both the scientific and lay media. It describes an initial study in transgenic mice, which had been developed as an animal model to test potential treatments for Alzheimer's disease.Scientifically, the paper is straightforward and impressive. The authors studied transgenic mice that overexpress a mutant form of the human amyloid precursor protein. The cerebral amyloidosis that develops in these animals is similar to that in the brains of patients with Alzheimer's disease.1 Cerebral amyloidosis was largely . . .