Bone Marrow Transplantation of Mice Exposed to a Modified Fission Neutron (N/G-30:1) Field

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Abstract
A special exposure design was used to yield a fission neutron dose-to-.gamma. dose (N/G) ratio of 30:1. The LD50/30 for mice exposed was 371 .+-. 4 rad, while 879 .+-. 14 rad (RBE [relative biological effectiveness] 2.4) was the LD50/30 for mice exposed to 60Co. A narrow dose range of 375-425 rad was found in which mice exposed in the modified fission field died 8-15 days later, a time frame characteristic of hematopoietic failure. In this dose rane, 5 .times. 106 syngeneic marrow cells resulted in 77% 30-day survival. The number of bone marrow cells needed to rescue neutron-irradiated mice was greater than the number needed to rescue 60Co-irradiated mice.

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