Chronic and Acute Effects of Dronedarone on the Action Potential of Rabbit Atrial Muscle Preparations: Comparison With Amiodarone
- 1 May 2002
- journal article
- research article
- Published by Wolters Kluwer Health in Journal of Cardiovascular Pharmacology
- Vol. 39 (5) , 677-684
- https://doi.org/10.1097/00005344-200205000-00008
Abstract
Dronedarone, a noniodinated derivative of amiodarone, is under evaluation as a potentially less toxic anti-arrhythmic alternative to amiodarone. The acute and chronic electrophysiologic effects of dronedarone and amiodarone were compared in isolated rabbit atrial muscle by microelectrode techniques. Four-week PO treatment with dronedarone or amiodarone increased action potential duration (APD90) (58 ± 4 ms control versus 69 ± 2 ms dronedarone, p 90Keywords
This publication has 34 references indexed in Scilit:
- Amiodarone to Prevent Recurrence of Atrial FibrillationNew England Journal of Medicine, 2000
- Evidence-Based Analysis of Amiodarone Efficacy and SafetyCirculation, 1999
- Antiarrhythmic Actions of Amiodarone: A Profile of a Paradoxical AgentThe American Journal of Cardiology, 1996
- Long-Term Efficacy of Amiodarone for the Maintenance of Normal Sinus Rhythm in Patients With Refractory Atrial Fibrillation or FlutterThe American Journal of Cardiology, 1995
- Block of cardiac sodium channels by amiodarone studied by using of action potential in single ventricular myocytesBritish Journal of Pharmacology, 1991
- Rate-related electrophysiologic effects of long-term administration of amiodarone on canine ventricular myocardium in vivo.Circulation, 1989
- Frequency-dependent effects of amiodarone on atrioventricular nodal function and slow-channel action potentials: evidence for calcium channel-blocking activity.Circulation, 1987
- Block of inactivated sodium channels and of depolarization-induced automaticity in guinea pig papillary muscle by amiodarone.Circulation Research, 1984
- The adrenergic antagonism of amiodaroneBiochemical Pharmacology, 1976
- The effect of amiodarone, a new anti‐anginal drug, on cardiac muscleBritish Journal of Pharmacology, 1970