THE INFLUENCE OF NEMBUTAL, PENTOTHAL, SECONAL, AMYTAL, PHENOBARBITAL, AND CHLOROFORM ON BLOOD SUGAR CONCENTRATION AND CARBOHYDRATE MOBILIZATION

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Abstract
Nembutal and amytal produce no change in the mean blood sugar levels at the time of deep anesthesia; phenobarbital causes none in the 1st hr.; pentothal and seconal bring about a rise in the 1st hr. All produce a fall in the blood sugar level at the time of recovery from anesthesia. All of the drugs cause a depression of the glycogenolytic power of the liver as evidenced by the relatively small effect of epinephrine on the blood sugar. The impaired glycogenolytic power of the liver is not related to the excretory processes taking place in the liver since phenobarbital, which is excreted by the kidneys, produces the same effect. Since chloroform also causes the same depression, the depression is probably not specific for the barbiturates, but may result from any liver damage.

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