Release of neuroactive substances: homocysteic acid as an endogenous agonist of the NMDA receptor
- 1 October 1988
- journal article
- review article
- Published by Springer Nature in Journal Of Neural Transmission-Parkinsons Disease and Dementia Section
- Vol. 72 (3) , 185-190
- https://doi.org/10.1007/bf01243418
Abstract
Sulfur containing amino acids such as homocysteic acid (HCA), cysteinsulfinic acid, homocysteinsulfinic acid are released by depolarization of slices from various rat brain regions in a Ca++-dependent manner. L-HCA excites caudate neurons through their N-methyl-D-aspartic acid (NMDA) receptor and potentiates their cortically evoked excitatory postsynaptic potentials.35S-methionine can label the releasable pool of HCA, and thus appears as a precursor of HCA. Thus HCA is a transmitter candidate which acts predominantly on the NMDA receptor.Keywords
This publication has 27 references indexed in Scilit:
- In Vitro Release of Endogenous Excitatory Sulfur‐Containing Amino Acids from Various Rat Brain RegionsJournal of Neurochemistry, 1986
- An N-methylaspartate receptor-mediated synapse in rat cerebral cortex: a site of action of ketamine?Nature, 1985
- An evaluation of selected brain constituents as putative excitatory neurotransmittersBrain Research, 1984
- II. Excitotoxic models for neurodegenerative disordersLife Sciences, 1984
- Potassium and veratrine-stimulated l-[3H]cysteine sulfinate and l-[3H]glutamate release from rat brain slices☆Neurochemistry International, 1984
- Quinolinic Acid: An Endogenous Metabolite That Produces Axon-Sparing Lesions in Rat BrainScience, 1983
- Anticonvulsant Action of Excitatory Amino Acid AntagonistsScience, 1982
- Cysteine Sulfinic Acid in the Central Nervous System: Uptake and Release of Cysteine Sulfinic Acid by a Rat Brain PreparationJournal of Neurochemistry, 1982
- CONVULSANT ACTIVITY OF HOMOCYSTEINE AND OTHER SHORT-CHAIN MERCAPTOACIDS: PROTECTION THEREFROMAnnals of the New York Academy of Sciences, 1969
- THE EXCITATION AND DEPRESSION OF SPINAL NEURONES BY STRUCTURALLY RELATED AMINO ACIDSJournal of Neurochemistry, 1960