Antagonism of Hydrochlorothiazide-Induced Elevations in Plasma-Renin Activity by Methyldopa in Conscious Renal-Hypertensive Dogs

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Abstract
Hydrochlorothiazide, 2.5 and 10 mg/kg per day, was administered alone and in combination with methyldopa, 200 mg/kg per day, and changes in plasma-renin activity and mean arterial blood pressure were measured in conscious hypertensive dogs during a 7-day treatment period. Hydrochlorothiazide did not lower mean arterial blood pressure although there was a substantial increase in plasma-renin activity. When methyldopa was administered in combination with hydrochlorothiazide, a significant decline in both blood pressure and plasma-renin activity was observed. Since methyldopa was hypotensive only when coadministered with hydrochlorothiazide, the results suggest that antihypertensive effects of methyldopa in the diuretic-treated dog may depend in part on suppression of renin release.

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