MUTATIONS AT MORE THAN ONE LOCUS MAY BE INVOLVED IN CYSTIC-FIBROSIS - EVIDENCE BASED ON 1ST-COUSIN DATA AND DIRECT COUNTING OF CASES

  • 1 January 1983
    • journal article
    • retracted article
    • Vol. 35  (5) , 838-844
Abstract
Cystic fibrosis was present in 35 of 5265 1st cousins of index cases with the disease. The gene frequency was estimated to be 0.0281 .+-. 0.00544, using an improved method that allows for the influence of cousin sibship size upon the estimate. This figure is higher than that obtained by direct counting of cases in Victoria, Australia, from 1955-1979 (0.0198 .+-. 0.000127), raising the possibility that multiple gene loci may be involved in this disease. Further analysis showed that the number of affected 1st cousins fitted very well with an expected number based on a model involving 2 gene loci, each responsible for 1/2 the cases of cystic fibrosis. Agreement with expectations based on a single locus was not good. An alternate explanation of gross underascertainment of cases is dismissed because the index sibships were shown to fit very closely a truncate binomial distribution. The gene frequencies at the putative 2 loci would then each be 0.0140 and heterozygote frequencies one in 36. One in 18 people would be heterozygous at either one or the other of the loci.

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