Effects of zincl-carnosine on gastric mucosal and cell damage caused by ethanol in rats

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Abstract
The effects of zincl-carnosine on ethanol-induced damage and the correlation of these effects with endogenous prostaglandin E2 were evaluated in rat gastric mucosain vivo andin vivo. When given either intragastrically or intraperitoneally, zincl-carnosine (10 or 30 mg/kg) prevented gross visible damage to gastric mucosa caused by ethanol without affecting the mucosal prostaglandin E2 level. This protective effect of zincl-carnosine was not inhibited by indomethacin. Histological assessment showed that zincl-carnosine inhibited deep mucosal necrosis, as did 16,16-dimethyl-prostaglandin E2. Zincl-carnosine (10−6 or 10−5 M) inhibited the damage caused by ethanol to gastric cells isolated from rat gastric mucosain vivo; this effect was not inhibited by indomethacin. The results suggested that zincl-carnosine protects the gastric mucosa and enhances cellular resistance to ethanol without the mediation of endogenous prostaglandins.