THE COLLOIDAL GOLD REACTION OF BLOOD SERUM IN DISEASES OF THE LIVER
- 1 March 1940
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of internal medicine (1960)
- Vol. 65 (3) , 524-544
- https://doi.org/10.1001/archinte.1940.00190090061005
Abstract
The purpose of this paper is to report studies of the colloidal gold reaction of blood serum in diseases of the liver. Zsigmondy,1 in 1901, laid the foundation for the diagnostic use of the colloidal gold reaction by observing that "certain colloids, especially proteins," prevented the precipitation of colloidal gold suspensions by electrolytes, each protein exerting a specific degree of protection against precipitation. On the other hand, Lange,2 in 1912, found that proteins within certain dilutions did not prevent but actually caused the precipitation. The mechanism of the colloidal gold reaction has been the subject of much investigation. Numerous workers, including Felton,3 Weston,4 Cruickshank5 and others,6 have shown that the globulin content is the determining factor in the precipitation of colloidal gold and that albumin protects the colloidal suspension from precipitation. The varying colloidal gold curves obtained with spinal fluids in different pathologic conditions result from variations in the balanceThis publication has 4 references indexed in Scilit:
- HEPATIC COMPLICATIONS IN THE TREATMENT OF SYPHILISAnnals of Internal Medicine, 1936
- RELATION OF PLASMA PROTEINS TO ASCITES AND EDEMA IN CIRRHOSIS OF THE LIVERArchives of internal medicine (1960), 1935
- BLOOD PLASMA PROTEIN GIVEN BY VEIN UTILIZED IN BODY METABOLISMThe Journal of Experimental Medicine, 1934
- HEPATIC COMPLICATIONS IN THE TREATMENT OF SYPHILISAnnals of Internal Medicine, 1934