Dose Response Analysis of GnRH Stimulation of hCG Release from Human Term Placenta1

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Abstract
The release of immunoreactive .alpha. and .beta. human chorionic gonadotropin (.alpha.hCG and .beta.hCG) from placental explants in vitro was stimulated by GnRH [gonadotropin releasing hormone] in a dose-response fashion, but human chorionic somatomammotropin was not affected. The stimulation of .alpha.hCG by GnRH (1, 2 or 5 .mu.g/ml) occurred on days 1-3 of culture,but this increase was dose-related only on days 2 and 3. A dose-related stimulation of the .beta.hCG release by GnRH was also observed on days 1, 2, 3, 7 and 8. Increased release of .beta.hCG was effected on day 4, using the highest dose of GnRH studied (5 .mu.g/ml). The cumulative release of .alpha.hCG during the 8 days of culture was not stimulated in a dose-response fashion by GnRH, while the increased cumulative release of .beta.hCG was dose-related.

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