Pathobiology of CD30+ cutaneous T‐cell lymphomas
- 13 January 2006
- journal article
- review article
- Published by Wiley in Journal of Cutaneous Pathology
- Vol. 33 (s1) , 10-17
- https://doi.org/10.1111/j.0303-6987.2006.00507.x
Abstract
CD30+ cutaneous lymphoproliferative disorders include lymphomatoid papulosis (LyP) and anaplastic large cell lymphoma (ALCL). LyP is associated with development of lymphoma in nearly 20% of patients. Herein is reviewed the clonal relationship of LyP to malignant lymphoma, the concept of a common stem cell for LyP and associated lymphomas, and the role of genetic instability in lymphomagenesis. The possible role of the CD30+ cell as a regulatory T-cell is introduced and a model for progression of LyP to ALCL is illustrated.Keywords
This publication has 38 references indexed in Scilit:
- Multilineage progression of genetically unstable tumor subclones in cutaneous T‐cell lymphomaExperimental Dermatology, 2004
- The NPM-ALK oncoprotein abrogates CD30 signaling and constitutive NF-κB activation in anaplastic large cell lymphomaCancer Cell, 2004
- Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3 The Journal of Experimental Medicine, 2003
- Bone marrow precursor of extranodal T-cell lymphomaBlood, 2003
- T Cell Receptor-γ Gene Analysis of CD30+ Large Atypical Individual Cells in CD30+ Large Primary Cutaneous T Cell LymphomasJournal of Investigative Dermatology, 2003
- Ligand-independent signaling by overexpressed CD30 drives NF-κB activation in Hodgkin–Reed-Sternberg cellsOncogene, 2002
- Cytogenetic findings in regressing skin lesions of lymphomatoid papulosisCancer Genetics and Cytogenetics, 1995
- Molecular evidence for a clonal relationship between lymphomatoid papulosis and Ki-1 positive large cell anaplastic lymphomaJournal of Dermatological Science, 1993
- Spectrum of primary cutaneous CD30 (Ki-1)-positive lymphoproliferative disorders: A proposal for classification and guidelines for management and treatmentJournal of the American Academy of Dermatology, 1993
- Clonal T-Cell Populations in Lymphomatoid PapulosisNew England Journal of Medicine, 1986