Four genes for the calpain family locate on four distinct human chromosomes
- 1 January 1990
- journal article
- research article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 53 (4) , 225-229
- https://doi.org/10.1159/000132937
Abstract
Calcium dependent proteases (calpains, CAPNs, E.C.3.4.22.17) constitute a family of proteins which share a homologous cysteine-protease domain (large subunits, L1 L2, and L3) and an E-F hand Ca2+-binding domain (L1, L2, L3, and small subunit, S). We have mapped the genes for four calpain proteins (L1 L2, L3, and S) on four distinct human chromosomes by a combination of spot-blot hybridization to flow-sorted chromosomes and Southern hybridization of DNAs from a human × mouse hybrid cell panel. The genes for calpain L1 (CAPNl, large subunit of calpain I), L2 (CAPN2, large subunit of calpain II), L3 (CAPN3, a protein related to the large subunits), and S (CAPN4, a small subunit common to calpains I and II) were assigned to human chromosomes 11, 1, 15, and 19, respectively.Keywords
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