Adenyl cyclase activity of rabbit aorta

Publisher Website
Google Scholar
Abstract
Adenyl cyclase activity in homogenates of thoracic and abdominal aorta from young and old rabbits was neither stimulated nor inhibited by isoprenaline, noradrenaline, 5-hydroxytryptamine, or histamine but was markedly increased by sodium fluoride. Sodium fluoride-stimulated adenyl cyclase activity was significantly higher in the abdominal than in the thoracic aorta. Neither the basal nor sodium fluoride-stimulated adenyl cyclase activity of thoracic aorta changed with increasing age of the aorta. On the other hand, the abdominal aorta showed an increase in sodium fluoride-stimulated activity but no change in basal activity with increasing age. After the ATP pool of intact thoracic aorta was prelabelled with [14C]-adenine, isoprenaline did not enhance the formation of labelled cyclic AMP in intact aortic strips. Based on these data no correlation could be made between adenyl cyclase activity and the β-receptor activity of this tissue.