Experimental Studies on the Local Effects of Acetyl-Choline, Anticholinergic Substances and Cholinesterase Inhibitors on Vestibular Function

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Abstract
A study has been made of the effects of acetylcholine, anticholinergic substances (atropine, tetraethylammonium) and cholinesterase inhibitors (dii-sopropylfluorophosphate), introduced into the endolymphatic duct, on vestibular function. The introduction of these substances into the endolymphatic duct was achieved by means of double fistulization of the lateral semicircular canal. Electronystagmography was used to investigate the functional effects of this procedure. From the findings obtained it seems possible to conclude that an accumulation of acetylcholine at the efferent nerve endings inhibits the transmission of afferent impulses, and that acetylcholine also takes part in the mechanism of transmission of nerve impulses from the neuroepithelial cell to the afferent fibre.