Efficient Synthesis of N,N-Disubstituted 5-Aminothiophene-2-carboxaldehydes by Nucleophilic Aromatic Substitution in Water
- 1 April 1998
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1998 (4) , 383-384
- https://doi.org/10.1055/s-1998-1657
Abstract
We have developed the first synthesis of N,N-disubstituted 5-aminothiophene-2-carboxaldehydes by nucleophilic aromatic substitution of 5-bromothiophene-2-carboxaldehyde in water. This study shows selectivity between primary and secondary amines leading to the corresponding imines or amino derivatives respectively.Keywords
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