Chemistry Underlying the Cardiotoxicity of Antihistaminest

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Abstract
Antihistamines are very useful therapeutic agents for the treatment of allergic diseases, and are one of the most frequently prescribed medicines world-wide. Despite the excellent safety record of antihistamines, the recent reports on cardiac toxicity associated with the use of antihistamines have caused wide-spread concerns among both the scientific community and the general public. This review delineates the molecular factors underlying this potentially devastating side effect of the otherwise . very safe therapeutics, including their pharmacodynamic activities on car d1ac potass1um channels and pharmacokinetic interactions with other therapeutic agents. The discussion is mainly based on structure-activity relationship of these agents and their cardiotoxicity, so to predict and prevent potential therapeutic hazards. Implications for future drug development as well as rational use of other therapeutic agents are also discussed.

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