SYNTHESIS OF MACROCYCLIC LACTONES APPLYING INTRAMOLECULAR 1,3-DIPOLAR CYCLOADDITION: SYNTHESIS OF (±)-A26771B
- 5 February 1982
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 11 (2) , 215-218
- https://doi.org/10.1246/cl.1982.215
Abstract
The intramolecular 1,3-dipolar cycloaddition of the nitrile oxides derived from ω-nitroalkyl acrylates gave isoxazoline fused macrocyclic lactones. The direction of 1,3-dipolar cycloaddition is strongly affected by the ring size of forming lactones. Utilizing this method, total synthesis of (±)-A26771B was achieved.Keywords
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