Application of Electrochemical Detection for the Quantitation of 1, 4-Dihydroxy-5, 8-Bis-[2-(2-Hydroxyethyl) Aminoethylamino]-9,10-Anthracenedione Following Liquid Chromatography
- 1 January 1983
- journal article
- research article
- Published by Taylor & Francis in Analytical Letters
- Vol. 16 (16) , 1343-1354
- https://doi.org/10.1080/00032718308065248
Abstract
Electrochemical monitoring of 1,4-dihydroxy-5,8-bis-[2-(2-hydroxyethyl)aminoethylamino]-9,10-anthracenedione was employed for the quantitation of this cancer chemotherapy drug following high performance liquid chromatography. Detection was performed by oxidation of the compound at a glassy C electrode at +0.80 V vs. SCE [saturated calomel electrode]. A rapid and convenient sample treatment procedure was developed which is suitable for determination involving physiological samples. A detection limit of 2 ng injected was obtained for [human] urine samples.This publication has 15 references indexed in Scilit:
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