Failure of Ethanol or Isopropanol Pretreatment to Affect Carbon Tetrachloride-Induced Inhibition of Hepatic Microsomal Calcium Pump Activity

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Abstract
The Ca pump of liver microsomes is sensitive to CCl4 metabolism in vitro and in vivo. Treatment of rats with alcohol might involve an enhancement of the action of low doses of CCl4 on the liver microsomal Ca pump. Treatment of fasted rats with isopropanol or ethanol potentiated the increase of serum glutamic oxaloacetic transaminase elicited by CCl4. Alcohol pretreatment alone had no effect on Ca pump activity. After CCl4 alone, the Ca pump was 50% inhibited at 20 min and 85% inhibited at 1 h. Pretreatment with either alcohol had no effect on rate of decline or extent of CCl4-dependent depression of the liver microsomal Ca pump. The mechanism of alcohol potentiation of CCl4-induced hepatotoxicity probably resided in alteration of processes developing after the initial events of CCl4 metabolism.