Absence of Association Between Oestrogen‐Receptor Content and in Vitro Oestrogen Sensitivity in Human Breast Cancer

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Abstract
Breast-cancer tissue from 25 consecutive patients was investigated for estrogen receptor content and for estrogen-induced changes in tritiated thymidine uptake by explanted cells. A higher estrogen receptor content was not associated with any statistically significant increase in estrogen sensitivity. Neither the Kd values, nor the estrogen binding capacity (f mol estrogen bound/mg supernatant protein) was found to be associated with in vitro estrogen sensitivity. One receptor-negative tumor showed estrogen sensitivity in vitro.