The stereochemistry of isocolumbin: X-ray analysis of the 1-p-iodophenyl-3-phenylpyrazoline adduct of isocolumbin
- 1 January 1966
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society B: Physical Organic
- p. 853-861
- https://doi.org/10.1039/j29660000853
Abstract
A suitable heavy atom derivative of isocolumbin has now been found in the 1-p-iodophenyl-3-phenylpyrazoline adduct (III) which crystallises as a monoacetone solvate in the tetragonal space group P41212 with eight molecules of C33H31O6N2I,(CH3)2CO in a unit cell of dimensions a=b= 9·68, c= 70·79 Å. With initial phasing on the iodine atom, the crystal structure was solved by three-dimensional Fourier and least squares calculations. The final value of R over 1860 independent reflections was 9·5%. The results establish structure (III) for this derivative and hence confirm structure (II) for isocolumbin. The molecular dimensions and the stereochemistry of the three boat shaped six-membered rings and the 0-lactone systems are discussed.Keywords
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