Biosynthesis of vitamin B12: the macrocycle and studies on the geminal methyl groups of ring c

1 January 1973

journal article
research article
Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications

No. 12,p. 404-405
https://doi.org/10.1039/c39730000404

Abstract

The biosynthesis of vitamin B₁₂ is studied by ¹³C-spectroscopy on the derived heptamethyl ester (4); work with amino[5-¹³C]lavulinic acid and [Me-¹³C]- methionine confirms that seven peripheral methyl groups are derived from methionine and proves that one of these is the pro-R methyl group on ring c.

Keywords

VITAMIN B12
METHYL GROUPS
METHIONINE
PERIPHERAL METHYL
HEPTAMETHYL ESTER
LAVULINIC ACID
SEVEN PERIPHERAL