Multiple signalling pathways exist in the stress‐triggered regulation of gene expression for catecholamine biosynthetic enzymes and several neuropeptides in the rat adrenal medulla
- 1 September 1999
- journal article
- review article
- Published by Wiley in Acta Physiologica Scandinavica
- Vol. 167 (1) , 1-9
- https://doi.org/10.1046/j.1365-201x.1999.00566.x
Abstract
A critical component of the response to stress is the coincident activation of the hypothalamic–pituitary–adrenal axis and the sympathoadrenal system – comprised of sympathetic ganglia and the adrenal medullae. The sympathoadrenal system produces the catecholamines – noradrenaline and adrenaline, and several neuropeptides, involved in the homeostatic mechanisms that govern the adaptation to stress. This brief survey aims to provide a general overview of the present knowledge about the impact of stress on neurotransmitter gene expression in the adrenal medulla, with particular attention paid to the apparent heterogeneity in stress-evoked signals and regulatory pathways.Keywords
This publication has 61 references indexed in Scilit:
- Repeated Immobilization Stress Increases the Binding of c-Fos-Like Proteins to a Rat Dopamine β-Hydroxylase Promoter Enhancer SequenceJournal of Neurochemistry, 2006
- Induction of Tyrosine Hydroxylase Protein and a Transgene Containing Tyrosine Hydroxylase 5′ Flanking Sequences by Stress in Mouse Adrenal GlandJournal of Neurochemistry, 1997
- Molecular Biology of Stress‐Elicited Induction of Catecholamine Biosynthetic EnzymesaAnnals of the New York Academy of Sciences, 1995
- Increase in Rat Adrenal Phenylethanolamine N‐Methyltransferase mRNA Level Caused by Immobilization Stress Depends on Intact Pituitary ‐ Adrenocortical AxisJournal of Neurochemistry, 1994
- Nicotinic Cholinergic Regulation of Tyrosine Hydroxylase Gene Expression and Catecholamine Synthesis in Isolated Bovine Adrenal Chromaffin CellsJournal of Neurochemistry, 1992
- Cold‐induced alterations in the binding of adrenomedullary nuclear proteins to the promoter region of the tyrosine hydroxylase geneJournal of Neuroscience Research, 1992
- Regulation of Tyrosine Hydroxylase and Dopamine β‐Hydroxylase mRNA Levels in Rat Adrenals by a Single and Repeated Immobilization StressJournal of Neurochemistry, 1992
- CREB: a Ca 2+ -Regulated Transcription Factor Phosphorylated by Calmodulin-Dependent KinasesScience, 1991
- Differential plasma catecholamine and neuropeptide Y responses to acute stress in ratsLife Sciences, 1988
- Biopterin Cofactor Biosynthesis: Independent Regulation of GTP Cyclohydrolase in Adrenal Medulla and CortexScience, 1981