Chromosome Abnormalities in Constitutional Aplastic Anemia

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Abstract
IN 1927 the condition now known as Fanconi's aplastic anemia was first described in 3 brothers with pancytopenia and multiple congenital anomalies.1 Since that time numerous reports have analyzed the clinical and hematologic aspects of this syndrome.2 3 4 It is now apparent that Fanconi's aplastic anemia is quite variable in its manifestations. Therefore, the designation "constitutional aplastic anemia" has been applied to all patients with aplastic anemia with or without congenital anomalies in whom a constitutional defect is suggested by the familial occurrence or congenital onset of the disease. Under this classification system Fanconi's aplastic anemia is considered as one variety . . .